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1992 1
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2002 11
2003 11
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605 results

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Page 1
Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation.
Roberts MA, Deol KK, Mathiowetz AJ, Lange M, Leto DE, Stevenson J, Hashemi SH, Morgens DW, Easter E, Heydari K, Nalls MA, Bassik MC, Kampmann M, Kopito RR, Faghri F, Olzmann JA. Roberts MA, et al. Dev Cell. 2023 Sep 25;58(18):1782-1800.e10. doi: 10.1016/j.devcel.2023.07.001. Epub 2023 Jul 25. Dev Cell. 2023. PMID: 37494933 Free article.
Despite the key roles of perilipin-2 (PLIN2) in governing lipid droplet (LD) metabolism, the mechanisms that regulate PLIN2 levels remain incompletely understood. Here, we leverage a set of genome-edited human PLIN2 reporter cell lines in a series of C …
Despite the key roles of perilipin-2 (PLIN2) in governing lipid droplet (LD) metabolism, the mechanisms that regulate PLIN2 …
Perilipin-2 limits remyelination by preventing lipid droplet degradation.
Loix M, Wouters E, Vanherle S, Dehairs J, McManaman JL, Kemps H, Swinnen JV, Haidar M, Bogie JFJ, Hendriks JJA. Loix M, et al. Cell Mol Life Sci. 2022 Sep 13;79(10):515. doi: 10.1007/s00018-022-04547-0. Cell Mol Life Sci. 2022. PMID: 36100764
To date, however, the mechanisms underlying LD biogenesis and breakdown in lipid-engorged phagocytes in the CNS, as well as their impact on foamy phagocyte biology and lesion progression, remain poorly understood. Here, we provide evidence that LD-associated protein perilipin …
To date, however, the mechanisms underlying LD biogenesis and breakdown in lipid-engorged phagocytes in the CNS, as well as their impact on …
Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation.
Wu Y, Chen K, Li L, Hao Z, Wang T, Liu Y, Xing G, Liu Z, Li H, Yuan H, Lu J, Zhang C, Zhang J, Zhao D, Wang J, Nie J, Ye D, Pan G, Chan WY, Liu X. Wu Y, et al. Cell Death Differ. 2022 Nov;29(11):2316-2331. doi: 10.1038/s41418-022-01018-8. Epub 2022 May 25. Cell Death Differ. 2022. PMID: 35614132 Free PMC article.
Upon exit from pluripotency, lipid droplet (LD)-associated protein Plin2 is recognized by Hsc70 and degraded via chaperone-mediated autophagy to facilitate LD mobilization. Enhancing lipid hydrolysis by Plin2 knockout promotes pluripotency exit, which is recovered b …
Upon exit from pluripotency, lipid droplet (LD)-associated protein Plin2 is recognized by Hsc70 and degraded via chaperone-mediated a …
The constitutive lipid droplet protein PLIN2 regulates autophagy in liver.
Tsai TH, Chen E, Li L, Saha P, Lee HJ, Huang LS, Shelness GS, Chan L, Chang BH. Tsai TH, et al. Autophagy. 2017 Jul 3;13(7):1130-1144. doi: 10.1080/15548627.2017.1319544. Epub 2017 May 26. Autophagy. 2017. PMID: 28548876 Free PMC article.
Lipid droplets are home to the lipid droplet proteins, the most abundant of which are the perilipins (PLINs), encoded by 5 different genes, Plin1 to Plin5. Of the corresponding gene products, PLIN2 is the only constitutive and ubiquitously expressed lipid droplet pr …
Lipid droplets are home to the lipid droplet proteins, the most abundant of which are the perilipins (PLINs), encoded by 5 different …
Perilipin 2-positive mononuclear phagocytes accumulate in the diabetic retina and promote PPARgamma-dependent vasodegeneration.
Blot G, Karadayi R, Przegralek L, Sartoris TM, Charles-Messance H, Augustin S, Negrier P, Blond F, Muñiz-Ruvalcaba FP, Rivera-de la Parra D, Vignaud L, Couturier A, Sahel JA, Acar N, Jimenez-Corona A, Delarasse C, Garfias Y, Sennlaub F, Guillonneau X. Blot G, et al. J Clin Invest. 2023 Oct 2;133(19):e161348. doi: 10.1172/JCI161348. J Clin Invest. 2023. PMID: 37781924 Free PMC article.
Here, we show that mononuclear phagocytes (MPs) in areas of vascular leakage in DR donor retinas expressed perilipin 2 (PLIN2), a marker of intracellular lipid load. Strong upregulation of PLIN2 was also observed when healthy donor Mos were treated with plasm …
Here, we show that mononuclear phagocytes (MPs) in areas of vascular leakage in DR donor retinas expressed perilipin 2 (PLIN2) …
Perilipin 2 (PLIN2)-deficiency does not increase cholesterol-induced toxicity in macrophages.
Son SH, Goo YH, Chang BH, Paul A. Son SH, et al. PLoS One. 2012;7(3):e33063. doi: 10.1371/journal.pone.0033063. Epub 2012 Mar 12. PLoS One. 2012. PMID: 22427949 Free PMC article.
Like in other cell types, PLIN2 deficiency impairs LD buildup in BMM. However, while most stress parameters were elevated in macrophages under ACAT inhibition and 7-KC loading, PLIN2 inactivation was well tolerated. The data support the safety of targeting PLIN2 …
Like in other cell types, PLIN2 deficiency impairs LD buildup in BMM. However, while most stress parameters were elevated in macropha …
Altered hepatic lipid droplet morphology and lipid metabolism in fasted Plin2-null mice.
Doncheva AI, Li Y, Khanal P, Hjorth M, Kolset SO, Norheim FA, Kimmel AR, Dalen KT. Doncheva AI, et al. J Lipid Res. 2023 Dec;64(12):100461. doi: 10.1016/j.jlr.2023.100461. Epub 2023 Oct 14. J Lipid Res. 2023. PMID: 37844775 Free PMC article.
Perilipin 2 (Plin2) binds to the surface of hepatic lipid droplets (LDs) with expression levels that correlate with triacylglyceride (TAG) content. We investigated if Plin2 is important for hepatic LD storage in fasted or high-fat diet-induced obese Plin2 …
Perilipin 2 (Plin2) binds to the surface of hepatic lipid droplets (LDs) with expression levels that correlate with triacylgly …
Alcoholic Setdb1 suppression promotes hepatosteatosis in mice by strengthening Plin2.
Zhang Y, Li Y, Liu Y, Wang H, Chen Y, Zhang B, Song M, Song L, Ding Q, Qiu J, Fan M, Qu L, Wang Z. Zhang Y, et al. Metabolism. 2023 Sep;146:155656. doi: 10.1016/j.metabol.2023.155656. Epub 2023 Jul 6. Metabolism. 2023. PMID: 37419179
Adenovirus-Setdb1 were produced to rescue the hepatic steatosis in both Setdb1-HKO and Lieber-De Carli mice. The enrichment of H3k9me3 in the upstream sequence of Plin2 and the chaperone-mediated autophagy (CMA) of Plin2 were identified by ChIP and co-IP. ...The dow …
Adenovirus-Setdb1 were produced to rescue the hepatic steatosis in both Setdb1-HKO and Lieber-De Carli mice. The enrichment of H3k9me3 in th …
Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis.
Kaushik S, Cuervo AM. Kaushik S, et al. Nat Cell Biol. 2015 Jun;17(6):759-70. doi: 10.1038/ncb3166. Epub 2015 May 11. Nat Cell Biol. 2015. PMID: 25961502 Free PMC article.
A potent physiological activator of CMA is nutrient deprivation, a condition in which intracellular triglyceride stores or lipid droplets (LDs) also undergo hydrolysis (lipolysis) to generate free fatty acids for energetic purposes. Here we report that the LD-associated proteins …
A potent physiological activator of CMA is nutrient deprivation, a condition in which intracellular triglyceride stores or lipid droplets (L …
Molecular mechanisms of perilipin protein function in lipid droplet metabolism.
Griseti E, Bello AA, Bieth E, Sabbagh B, Iacovoni JS, Bigay J, Laurell H, Čopič A. Griseti E, et al. FEBS Lett. 2023 Dec 23. doi: 10.1002/1873-3468.14792. Online ahead of print. FEBS Lett. 2023. PMID: 38140813 Review.
Perilipins are abundant lipid droplet (LD) proteins present in all metazoans and also in Amoebozoa and fungi. ...PLIN1 and PLIN5 play a direct role in lipolysis by regulating the recruitment of lipases to LDs and LD interaction with mitochondria. Other perilipins, p …
Perilipins are abundant lipid droplet (LD) proteins present in all metazoans and also in Amoebozoa and fungi. ...PLIN1 and PLIN5 play …
605 results